Bad bumps to head could kill years later: U.S. study | Reuters

Drugs which includes your hormone progesterone, monoclonal antibodies and the antibiotic minocycline are now being studied to ascertain if they are able to stop the entire method of nerve destruction which follows injuries such as being a blow for the head or perhaps stroke.

Scientists know that damaging 1 nerve can sometimes tripped any cascade regarding some other nerves dying, regarding factors that remain poorly understood. TDP-43 could potentially be involved.


"If you might somehow give a individual a drug, you could potentially stop an illness just like amyotrophic lateral sclerosis," Dr. Jeffrey Bazarian of the University Or College associated with Rochester Healthcare center in Ny mentioned in the phone interview.

"This is the initial pathological evidence that repetitive head trauma experienced throughout collision sports may be connected with the development of the motor neuron disease," Dr. Ann McKee regarding Boston University Or Co llege school associated with Medicine and colleagues wrote in the report, offered at

McKee's team studied the donated mind and spinal cords regarding 11 expert football players or even boxers and one hockey player. Almost All had a newly characterized disease called chronic traumatic encephalopathy, or even CTE, in which dementia emerge years after repeated concussions.

"We believe there currently are very different forms of ALS," she stated -- potentially with different causes.

The researchers looked specifically for any protein referred for you to as TDP-43. These People discovered it in the brain and in the spinal cords of the men -- that could explain the particular ALS-like symptoms.

Experts in mind injury mentioned your study, printed inside the Journal of Neuropathology & Experimental Neurology, pointed to become able to new areas regarding study as well as feasible ways to stop long-term damage coming from concussions.

"Whether by itself throughout isolation it leads to ALS, I don't think that paper proves that. what I feel it does is raise worries that people which stood a profession of exposure in order to repeat concussions ... use a greater probability associated with creating motor neuron disease," he said.

David Hovda, director with the UCLA Traumatic Mind Injury Study Center, stated mind injury is very common with 1.5 million cases in the united States by yourself each year.


WASHINGTON Scientists reported on Tuesday they've a couple of regarding the very best evidence but to guide long-held theories which repeated blows for the head might cause nerve-degenerative diseases similar to Lou Gehrig's disease as well as Alzheimer's.

Bazarian, who has been simply with an Institute of Medicine Committee that will introduced the report throughout 2008 linking concussions in order to later-life neurologic diseases, stated the actual obtaining may help explain studies that show Iraq war veterans use a higher-than-normal rate involving ALS, regarding example.

All had repeated concussions throughout their particular careers. three in the men have been identified as having amyotrophic lateral sclerosis, in addition called ALS or perhaps Lou Gehrig's disease, the star baseball player who died associate d with it.

The findings additionally point for an urgent must watch veterans with the wars in Iraq and also Afghanistan, many of whom suffer brain injuries through explosions, accidents as well as blows for the head from other causes, the particular experts said.

Autopsies regarding 12 athletes whom died together with brain or even neurological disease confirmed a new distinctive pattern involving nerve damage -- and fingered a amount of prospective culprits.

Three in the men additionally had been diagnosed with ALS, a part of a family associated with diseases referred in order to as motor neuron disease, which in turn cause progressively a whole lot worse paralysis.

(Editing by simply Philip Barbara)

The findings will probably be hard to substantiate because ALS is so rare, said ALS expert Martina Wiedau-Pazos with the University Or College associated with California Los Angeles.


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